Characterization of Mycobacterium tuberculosis strains in Beijing, China: drug susceptibility phenotypes and Beijing genotype family transmission
نویسندگان
چکیده
منابع مشابه
Risk factors and clinical phenotypes of Beijing genotype strains in tuberculosis patients in China
BACKGROUND Beijing genotype strains are the most predominant strains in China. The aim of this study was to explore risk factors and clinical phenotypes associated with infection with Beijing genotype strains among tuberculosis patients in China. METHODS Using data and strains derived from the first Chinese national drug resistance base-line survey, we performed a statistical analysis of the ...
متن کاملFitness of Mycobacterium tuberculosis Strains of the W-Beijing and Non-W-Beijing Genotype
BACKGROUND Multidrug resistant tuberculosis (MDR-TB) is a major threat for global tuberculosis control. The W-Beijing Mycobacterium tuberculosis genotype has been associated with drug resistance. Elucidation of the mechanisms underlying this epidemiological finding may have an important role in the control of MDR-TB. The aim of this study was to evaluate the fitness of drug-susceptible and MDR ...
متن کاملNon-Beijing strains of Mycobacterium tuberculosis in China.
In a 2-year prospective study of tuberculosis (TB) patients in China, the prevalences of non-Beijing strains of Mycobacterium tuberculosis varied between Shandong Province (20.6%), Shanghai (27.6%), and Sichuan Province (45.9%) (P < 0.005). These differences may be due to factors such as human migration, transmission, or diversification and adaptation of the mycobacteria to different hosts.
متن کاملBeijing/W Genotype Mycobacterium tuberculosis and Drug Resistance
Beijing/W genotype Mycobacterium tuberculosis is widespread, may be increasing, and may have a predilection for drug resistance. Individual-level data on >29,000 patients from 49 studies in 35 countries were combined to assess the Beijing genotype's prevalence worldwide, trends over time and with age, and associations with drug resistance. We found 4 patterns for Beijing/W genotype tuberculosis...
متن کاملMolecular characterization of drug-resistant Beijing family isolates of Mycobacterium tuberculosis from Tianjin, China.
OBJECTIVE Tuberculosis remains a severe public health issue, and the Beijing family of mycobacterium tuberculosis (M. tuberculosis) is widespread in East Asia, especially in some areas in China, like Beijing and Tianjin. This study aimed at determining the mutation patterns of drug-resistant Beijing strains of M. tuberculosis isolated from Tianjin, China. METHODS A total of 822 M. tuberculosi...
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ژورنال
عنوان ژورنال: BMC Infectious Diseases
سال: 2018
ISSN: 1471-2334
DOI: 10.1186/s12879-018-3578-7